The low-molecular-weight heparin dalteparin as adjuvant therapy in acute myocardial infarction: The ASSENT PLUS study
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منابع مشابه
Acute Myocardial Infarction Low Molecular Weight Heparin (Dalteparin) as Adjuvant Treatment to Thrombolysis in Acute Myocardial Infarction—A Pilot Study: Biochemical Markers in Acute Coronary Syndromes (BIOMACS II)
METHODS In 101 patients dalteparin/placebo 100 IU/kg was given just before streptokinase and a second injection 120 IU/kg after 12 h. Monitoring with continuous vector-ECG was done to obtain signs of early reperfusion and later ischemic episodes. Blood samples for myoglobin were obtained at start and after 90 min to evaluate signs of reperfusion. Coronary angiography was performed after 20–28 h...
متن کاملLow molecular weight heparin (dalteparin) compared to unfractionated heparin as an adjunct to rt-PA (alteplase) for improvement of coronary artery patency in acute myocardial infarction-the ASSENT Plus study.
BACKGROUND Current thrombolytic-antithrombotic regimens in acute myocardialinfarction (AMI) are limited by incomplete early coronary reperfusion and by reocclusion and reinfarction. We compared the effects of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) as an adjunct to recombinant tissue-plasminogen activator (alteplase) on coronary artery patency and clinical outcom...
متن کاملEffect of dalteparin, a low-molecular-weight heparin, as adjunctive therapy in patients with Kawasaki disease: a retrospective study
BACKGROUND Dalteparin, a low-molecular-weight heparin, has anticoagulant and anti-angiogenic activity. This study investigated whether dalteparin reduced coronary artery lesion (CAL) prevalence, and resistance to intravenous immunoglobulin (IVIG) therapy in Kawasaki disease (KD). METHODS This retrospective study comprised two parts. In the first cohort, 126 patients with KD (68 male, 58 femal...
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T he Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment (ExTRACT)–Thrombolysis in Myocardial Infarction (TIMI)-25 study demonstrated that the administration of enoxaparin sodium, 30 mg intravenously, followed by subcutaneous injections of 1 mg/kg twice daily (dose modified in patients 75 years or older), compared with intravenous unfractionated heparin (UFH), 60 U...
متن کاملLow-molecular-weight dextran in acute myocardial infarction.
In spite of vasopressor agents, anti-arrhythmic drugs, early ambulation, and anticoagulant therapy the mortality among patients with acute myocardial infarction is almost 40%/,O . Intensive-care units may reduce this figure, but other attempts to lower the mortality should be sought. Langsjoen et al. (1963) reported the beneficial effect of low-molecular-weight dextran (mean molecular weight 40...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 2001
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960241305